The first Moodfluffies were only genetically modified ferals, which were injected with a formula on their neck and thrown into a makeshift saferoom of Happy Fluffy Co.'s facility.
There, the only emotion this smarty (surprising though, as he could easily be deemed the poopie of the group) showed was anger, and he killed his special friend mid-coitus, then his babbehs, then his entire herd of already weak and neglected fluffies.
And he wanted even more, so they had to neutralize him with a lethal gas, the first test was a absolute failure, as expected.
He begged for life once he noticed he was slowly fading away, but it was too late. The gas had already consumed the entire glass chamber.
His body was studied for some days and then thrown into the incinerator.
Ooh that gives me an idea, what if there were a sort of nerve gas that affects them emotionally? So regardless of what is going on you could forcefully induce a certain emotion against their will in a way similar to mind control.
Start cutting off legs but administer happy gas so although it has tears streaming from the pain and desperately wants to protest and beg to keep its legs, it is unable to manage the conflicting emotions in its simple mind and the gas overrides the fluffy’s free will resulting in smiles, declarations of love to the abuser as well as the knife itself, thanking you for amputating, and begging you NOT to stop.
A hormonal couple in “love” trying to make babies, but you administer angry gas to one or both of them so while they’re enfing they’re brain is forced against their will to say that they hate each other, causing them to be deeply confused and emotionally destroyed.
A happy, excited, pregnant, couple on the verge of giving birth.
Administer gas to the father causing murderous rage despite him being a good parent who loves all of his babies, his body would react and stomp all of the newborns against his will as if he has taken the back seat in his own mind.
A good mother giving birth while “despair” gas is administered. She legitimately loves all of her babies as each one comes out perfectly healthy, but the gas causes her to feel inexplicably distraught and terrified of her babies. Against her own will, she begs her human “daddy” to do something about the “monster babies” while she is still immobilized and so he slowly squishes each one in front of her.
Or flip that one: all of her babies are deformed and terrifying, but “happy” gas forces her to clean, snuggle, and feed all of the monsters as if they were healthy, all the while her internal monologue is disgusted and terrified. Possibly even neglecting healthy babies to care for a deformed stillbirth.