I have just realized when playing a card game with my friends that i can’t believe i overlooked this so hear me out.
What if you made a crossover with Fluffies in The Binding of Isaac?
You swap the explorers with Fluffies that are dropped into a basement and mudt explore to get out whilst trying to survive against monsters both bizarre and gross as well as the strange or dangerous traps or items in shops and rooms. I can kinda visualize this in the style of Turbine’s Spelunker comic or Gr1m’s comics.